Prediction and causal explanation are fundamentally distinct tasks of data analysis. In health applications, this difference can be understood in terms of the difference between prognosis (prediction) and prevention/treatment (causal explanation). Nevertheless, these two concepts are often conflated in practice. We use the framework of generalised linear models (GLMs) to illustrate that predictive and causal queries require distinct processes for their application and subsequent interpretation of results. In particular, we identify five primary ways in which GLMs for prediction differ from GLMs for causal inference: (1) The covariates that should be considered for inclusion in (and possibly exclusion from) the model; (2) How a suitable set of covariates to include in the model is determined; (3) Which covariates are ultimately selected, and what functional form (i.e. parameterisation) th

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